Detailed Information
Basic Information
| BastionHub ID | SS00408 |
| UniProt ID | O30916 |
| NCBI ID | WP_001166946.1 |
| Gene Name | sopB |
Brief Description
|
Inositol phosphate phosphatase SopB (UniProt) |
| Secretion System Type | Type III secretion system (T3SS) |
| Species | Salmonella enterica |
| Gene Ontology Terms | GO:0071944;GO:0020003;GO:0042577;GO:0030308;GO:0023057;GO:0009405;GO:0045740;GO:0045859 |
| Function | Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell. lipid phosphatase activity, negative regulation of cell growth, negative regulation of signaling, pathogenesis, positive regulation of DNA replication and regulation of protein kinase activity. (UniProt) |
| Sequence | MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKASNHSLHNLYNLQRDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQDGLPAKEAHRFAAVAFRDAQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDKTLFCGIRHGVLSPYHEKDPLLRHVGAENKAKEVLTAALFSKPELLNKALAGEAVSLKLVSVGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKREIISLHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLITS |
| Length | 561 amino acids |
| PubMed ID | 23437191 |
Protein 3D Structure
| PDB Accession | Method | Resolution | Chain | Structure Review |
|---|---|---|---|---|
| 4DID | X-ray | 2.35 A | B=30-181. | 4DID |
Disorder Area
Molecule Processing
| Feature Key | Position(s) | Description | Length | PMID |
|---|---|---|---|---|
| Chain(PRO_0000220495) | 1-561 | Inositol phosphate phosphatase SopB | 561 | - |
Post-translational Modification
Sorry. There is no result for this protein entry.
Metabolic Pathway Summary
| Event | Description | PMID |
|---|---|---|
| Sorry. There is no result for this protein entry. | ||
Enzymatic and Metabolic Pathway
| Database | ID |
|---|---|
| BioCyc | SENT99287:STM1091-MONOMER |
| BioCyc | MetaCyc:MONOMER-15186 |
| BRENDA | 3.1.3.78 5542 |
Pathogen-Host Interaction
| PHI | Gene | Disease | Year | Host species | Experimental | Mutant |
|---|---|---|---|---|---|---|
| 7920 | sopB | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 8298 | SopB | Salmonellosis | 2018 | Homo sapiens (related: human) | Gene deletion: full; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopE2 | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopA | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopB | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopA | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopE2 | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 8298 | SopB | Salmonellosis | 2018 | Homo sapiens (related: human) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopB | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7236 | SopB | Salmonellosis | 2017 | Homo sapiens (related: human) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopB | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopE2 | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sipA | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 6738 | sopB | Food poisoning and gastroenteritis | 2016 | Homo sapiens (related: human) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
| 7920 | sopB | Salmonellosis | 2018 | Mus musculus (related: house mouse) | Gene mutation; gene complementation | effector (plant avirulence determinant) |
Protein Family
Belongs to the phosphatase IpgD/SopB family.
Similar Protein
Multiple Sequence Alignments
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